Impact of pre-adapted HIV transmission
Created 1 year ago
A brief overview of this publication. HIV adapts to the immune responses in each host. The specific mutations that are selected can be predicted based on the host's HLA types. This allows us to train a model of adaptation and ask the question: What is the clinical impact of within-host and transmitted adaptation? We find that both are detrimental to the immune response and predict accelerated disease progression. That transmission of pre-adapted HIV has such long term consequences suggests HIV exploiting universal holes in the immune response. In this mix, we walk through the data and implications of these findings.
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