Brown Adipose tissue in Adults video recording

17650292-Aya Almajzoub

BrownAdiposeAdultsAdvanced PhysiologyAyaAlmajzoub17650292
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Brown Adipose tissue in Adults video recording

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17650292-Aya Almajzoub
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  1. Brown Adipose tissue in Adults

    Slide 1 - Brown Adipose tissue in Adults

    • Aya Almajzoub 17650292
  2. Description and function of BAT

    Slide 2 - Description and function of BAT

    • (wiki, 2005)
    • BAT is one of two source of fat (adipose tissues) in humans.
    • BAT generates heat in humans when In need (Gesta et al .,2008).
    • Presence of BAT is crucial for classical nonshivering thermogenesis , adaptive adrenergic thermogenesis ,diet induced thermogenesis and antiobesity (Nedergaard et al., 2007).
    • Previously it was a common conception that BAT was lost after a few years of birth (Nedergaard et al., 2007).
    • Absence of BAT in human adults was a generally accepted belief.
  3. Detection of BAT in human adults

    Slide 3 - Detection of BAT in human adults

    • Recent studies carried out in 2002 using (PET) scanning have indicated that BAT is still available in adults .
    • Glucose uptake indicate presence of tumor and (FDG) follows glucose uptake.
    • Some non tumor tissues require glucose uptake in symmetrically distributed areas, but tumors aren't symmetrically distributed.
    • Using (PET) it was reported symmetrical areas had characteristics of adipose tissues .
    • (Nedergaard et al., 2007)
    • (Cold but not sympathomimetics activates human brown adipose tissue in vivo, 2012)
  4. Location of BAT in adults and relation to FDG uptake

    Slide 4 - Location of BAT in adults and relation to FDG uptake

    • BAT are mostly visible in supraclavicular and neck area in adults (Hany et al., 2002) .
    • Pattern of BAT is also evident along spinal cord area (Hany et al., 2002) .
    • Studies confirmed existence FDG uptake is present in areas of BAT(Nedergaard et al., 2007).
    • Elimination of BAT led to reduction of FDG uptake (Nedergaard et al., 2007).
    • (Nedergaard et al., 2007)
  5. BAT role in glucose uptake

    Slide 5 - BAT role in glucose uptake

    • BAT has significant role in glucose metabolism as it disposes glucose outside nervous system (in resting and fasting state studied).
    • BAT helps clear glucose from circulation
    • Presence of UCP1 in tissue identifies the characteristic of BAT.
    • (Nedergaard et al., 2007)
  6. Thermogenesis in BAT

    Slide 6 - Thermogenesis in BAT

    • BAT is thermogenic relevant
    • FDG Uptake reflects stimulation of glucose uptake. Glucose uptake in tissues demonstrate metabolic active in form of thermogenesis FDG uptake is present in active BAT (Nedergaard et al., 2007).
    • FDG uptake in warm temperature are suppressed  BAT is inactive (Garcia CA, 2015)
    • FDG uptake in cold temperature is incited  BAT is active (Garcia CA, 2015)
    • BAT is determined by environmental temperature in acute conditions (Garcia CA, 2015) .
    • (Nedergaard et al., 2007)
  7. BAT in association to age ,sex and weight

    Slide 7 - BAT in association to age ,sex and weight

    • Based on collected evidence prevalence of BAT have suggested to be in tens of percent (Nedergaard et al., 2007).
    • Age doesn’t play a big role in exhibition of BAT but in one study there was decline in BAT proportion with age (Sturkenboom et al., 2004) .
    • Studies indicate that female adult display more BAT than males but these report are under further examination (Nedergaard et al., 2007) .
    • Some studies claim a correlation between possession of active BAT and low BMI (Nedergaard et al., 2007) .
    • (Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans, 2013)
  8. Conclusion

    Slide 8 - Conclusion

    • BAT is present and active in Adult humans
    • Large uptakes of BAT is located in supraclavicular and neck region
    • BAT is visible in areas of FDG uptake
    • FDG indicates active BAT
    • Activity of BAT is induced by acute Exposure to cold
  9. Thank you for listening

    Slide 9 - Thank you for listening

  10. Reference

    Slide 10 - Reference

    • Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans. (2013). [image] Available at: http://www.e-dmj.org/ArticleImage/2004DMJ/dmj-37-22-g003-l.jpg [Accessed 13 May 2015].
    • Cold but not sympathomimetics activates human brown adipose tissue in vivo. (2012). [image] Available at: http://www.pnas.org/content/109/25/10001/F2.large.jpg [Accessed 13 May 2015].
    • Garcia CA, e. (2015). Reduction of brown fat 2-deoxy-2-[F-18]fluoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan: Available from PubMed - NCBI. [online] Ncbi.nlm.nih.gov [Accessed 17 Apr. 2015].
    • Gesta, S., Tseng, Y. and Kahn, C. (2008). Developmental Origin of Fat: Tracking Obesity to Its Source. Cell, 135(2), p.366.
    • Hany, T., Gharehpapagh, E., Kamel, E., Buck, A., Himms-Hagen, J. and von Schulthess, G. (2002). Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. European Journal of Nuclear Medicine and Molecular Imaging, 29(10), pp.1393-1398.
    • Nedergaard, J., Bengtsson, T. and Cannon, B. (2007). Unexpected evidence for active brown adipose tissue in adult humans. AJP: Endocrinology and Metabolism, 293(2), pp.E444-E452.
    • Sturkenboom, M., Franssen, E., Berkhof, J. and Hoekstra, O. (2004). Physiological uptake of [18F]fluorodeoxyglucose in the neck and upper chest region: are there predictive characteristics?. Nuclear Medicine Communications, 25(11), pp.1109-1111.
    • wiki, (2005). Brown Adipose Tissue. [image] Available at: http://www.discountgarciniacambogiaextract.com/img/Brown-fat-to-fight-white-fat.jpg [Accessed 12 May 2015].