DESCRIPTION OF THE MECHANISMS INVOLVED IN INCREASING MOTOR AXON

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DESCRIPTION OF THE MECHANISMS INVOLVED IN INCREASING MOTOR AXON

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  1. DESCRIPTION OF THE MECHANISMS INVOLVED IN INCREASING MOTOR AXON REGENERATION AFTER INJURY

    Slide 1 - DESCRIPTION OF THE MECHANISMS INVOLVED IN INCREASING MOTOR AXON REGENERATION AFTER INJURY

    • Melissa Smith 17267175
  2. CONTENT

    Slide 2 - CONTENT

    • INTRODUCTION
    • ANATOMY OF THE PERIPHERAL NERVE
    • REGENERATION OF AXONS
    • NEUROTROPHIC FACTORS
    • SURGICAL REPAIR
    • RESEARCH FINDINGS
    • CONCLUSIONS
    • REFERENCES
  3. Introduction

    Slide 3 - Introduction

    • Nerves
    • Fascicles
  4. ANATOMY OF PERIPHERAL NERVES

    Slide 4 - ANATOMY OF PERIPHERAL NERVES

    • Peripheral nerve
    • Connective tissue
    • Nerve components
    • Endonerurium
    • Perineurium
    • Epinerurium
    • Nerve Fibres
  5. Regeneration  of Axons.Nerve RegenerationSchwann cellsSevere Nerve InjuryMotor NerveSensory Nerve

    Slide 5 - Regeneration of Axons.Nerve RegenerationSchwann cellsSevere Nerve InjuryMotor NerveSensory Nerve

  6. Regeneration of Nerve FibersThe Cellular and Molecular Basis of Peripheral Nerve Repair

    Slide 6 - Regeneration of Nerve FibersThe Cellular and Molecular Basis of Peripheral Nerve Repair

  7. Neurotrophic FactorsProteinsNerve Growth Factor (NGF)Growth Factor

    Slide 7 - Neurotrophic FactorsProteinsNerve Growth Factor (NGF)Growth Factor

  8. Surgical RepairEpineural RepairFascicular RepairGrafting Repair

    Slide 8 - Surgical RepairEpineural RepairFascicular RepairGrafting Repair

    • (Flores et al. 2000)
    • (Evans 2001)
  9. 			Research Findings

    Slide 9 - Research Findings

    • (Gordon et al.2009)
  10. ConclusionThe peripheral nerve response of an injury is unique as it has the ability to regenerate lost connections. The CNS does not share this same ability. However, further research is needed for better advances in surgical and therapeutic treatments for PNI injury.

    Slide 10 - ConclusionThe peripheral nerve response of an injury is unique as it has the ability to regenerate lost connections. The CNS does not share this same ability. However, further research is needed for better advances in surgical and therapeutic treatments for PNI injury.

  11. References

    Slide 11 - References

    • Burnett, G.M, MD & Zager, I. E, MD 2004, Pathophysiology of peripheral nerve injury: a brief review, Neurosurg Focus, vol.16
    • Evans, R.D.G 2001, Peripheral Neve injury: A Review and Approach to Tissue enginerred Constructs, The Anatomical record, vol. 263, pp. 396-404.
    • Flores, J.A, MD, Lavernia, J. C,MD & Owens W.P, MD March 2000, Anatomy and physiology of peripheral injury and repair, The American Journal of Orthopedics.
    • Gordon, T, Chan, M.K, Sulaiman, A.R. O, Udina, E, Amirjani, N & Brushart, T.M 2009, Accelerating Axon Growth to Overcome Limitations in Functional Recovery After Peripheral Nerve Injury, vol. 65, No. 4.
    • Martini F. H, Ober W.C & Nath J.L 2011, Visual Anatomy and Physiology, Pearson Education, INC, U.S.A
    • Near,L.S, Whalen, L. R, Miller, A.J & Ishh, N. D 1992, Insulin-like growth factor II stimulates motor nerve regeneration, Neurobiology, vol. 89, pp. 11716-11720
    • Purves, D, Augustine, J. G, Fitzpatrick, D, Hall, C.W, LaMantia, A.S & White, E.L 2012, Neuroscience, Fifth Edition, Sinauer Associates, Inc, U.S.A
    • Saladin, K.S 2010, Anatomy and Physiology: The Unity of Form and Function, Fifth Edition, the McGraw-Hill Companies, Inc, New York.
    • Wein, D, Novikova, N.L, Wiberg, M, Kellerth, O.J & Novikov. N, L 2008 Survival and regeneration of cutaneous and muscular afferent neurons after peripheral nerve injury in adult rats, Exp Brain Res, vol. 186, pp. 315-323.