sandy ieleshaa

TAFA4, Sensory

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sandy ieleshaa

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TAFA4, Sensory
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  1. TAFA4 Modulates Chemical And Mechanical Pan After Nerve Injury

    Slide 1 - TAFA4 Modulates Chemical And Mechanical Pan After Nerve Injury

    • Review the evidence for the role of CLTMs in pain after
    • (Gel-coated implants could reverse paralysis caused by nerve damage)
  2. Chemical and Mechanical pain after nerve injury

    Slide 2 - Chemical and Mechanical pain after nerve injury

    • Touch is vital
    • Damage impulses
    • Touch sensation
    • Physiology and morphological lay
    • Cell bodies
    • Dorsal root
    • (MedicineNet.com)
  3. TAFA4?

    Slide 3 - TAFA4?

    • Is protein
    • Sensory neutrons
    • Prevent pain after injury
    • C-low threshold mechanoreceptors (C-LTMRs)
  4. TAFA4 Experiment

    Slide 4 - TAFA4 Experiment

    • In France studies were carried out on by Aziz Moqrich of Aix-Marseille-university.(Delfini et al.)
    • TAFA4 could stop hypersensitivity
    • Mice that doesn't contain TAFA4
    • TAFA4 abolishing hypersensitivity
    • (Delfini et al.)
  5. CLTMs?

    Slide 5 - CLTMs?

    • Are unmyelinated (Li 2011)
    • Mammals's Hairy skin
    • Transport of pleasant touch sensations
  6. Evidence

    Slide 6 - Evidence

    • Transducers of pleasant touch
    • Painful touch after injury
    • Qiufu Ma from Harvard Medical Science revealed that:
    • Without presence of CLTMs
    • Preventing their development
    • Levels of hypersensitivity
  7. Who is Qiufu Ma?

    Slide 7 - Who is Qiufu Ma?

    • Neurobiology
    • Research on two areas
    • 1- understand genetic program
    • > control specific sensory labelled
    • 2- characterize neural circuits
    • > Interaction distinct sensory labelled
    • (Ma)
  8. Qiufu Ma Popular Quote

    Slide 8 - Qiufu Ma Popular Quote

    • " We are interested in studying the neural
    • Circuits involved with the
    • Sense of pain, itch, touch
    • And temperature" (Ma)
  9. Study conducted by Delfini et al. (2013)

    Slide 9 - Study conducted by Delfini et al. (2013)

    • Study conducted by Delfini et al. (2013)
    • Chemokine-like secreted protein TAFA4
    • C-low-threshold (CLTMs)
    • Suggestions
    • TAFA4 resist pain
    • Glutamate from C-LTMRs
    • Loss of glutamate
    • Resistance to hypersensitivity
    • Loss of C-LTMRs
    • Removes the following:
    • 1- Glutamate
    • 2- TAFA4 protein
  10. Conclusion

    Slide 10 - Conclusion

    • TAFA4 has claiming effect on hypersensitivity
    • TAFA4 resist pain by the promotion of glutamate release in CLTMs.
    • CLTMs and TAFA4 work together
    • Lower hypersensitivity
    • CLTMs release glutamate through TAFA4
    • TAFA4 induces outward current in spinal cord neurons
    • Inputs from CLTMs
    • Excited spinal cord neurons
  11. References:

    Slide 11 - References:

    • 1- Coxworth, Ben. 2015. Web. 31 Mar. 2015.
    • 2- Delfini MC, et al. 'TAFA4, A Chemokine-Like Protein, Modulates Injury-Induced Mechanical And Chemical Pain Hypersensitivity In Mice. - Pubmed - NCBI'. Ncbi.nlm.nih.gov. N.p., 2015. Web. 29 Mar. 2015.
    • 3- Delfini, Marie-Claire et al. 'TAFA4, A Chemokine-Like Protein, Modulates Injury-Induced Mechanical And Chemical Pain Hypersensitivity In Mice'. Cell Reports 5.2 (2013): 378-388. Web. 27 Mar. 2015.
    • 4- Gel-coated implants could reverse paralysis caused by nerve damage,. New Technology Could Facilitate The Healing Of Damage Nerves. 2015. Web. 16 Apr. 2015
    • 5- Li, L. (2011). The functional organization of cutaneous low-threshold mechanosensory neurons. - PubMed - NCBI. [online] Ncbi.nlm.nih.gov. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22196735 [Accessed 31 Mar. 2015].
    • 6- MedicineNet.com,. Multiple Sclerosis Pictures, Symptoms And Treatment. 2015. Web. 12 Apr. 2015.
    • 7- Seal, R. (2009). Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. - PubMed - NCBI. [online] Ncbi.nlm.nih.gov. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19915548 [Accessed 31 Mar. 2015].
    • 8- Solis, Michele. 'TAFA4 Protein Calms Painful Touch'. Pain Research Forum. N.p., 2015. Web. 30 Mar. 2015.
    • 9- Woolf, Clifford J. 'Pain Hypersensitivity'. Wellcome.ac.uk. N.p., 2015. Web. 30 Mar. 2015.
  12. Name: Sandy Ieleshaa

    Slide 12 - Name: Sandy Ieleshaa

    • SID: 17521736
    • Thank you