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Slide 1 - TAFA4 Modulates Chemical And Mechanical Pan After Nerve Injury
- Review the evidence for the role of CLTMs in pain after
- (Gel-coated implants could reverse paralysis caused by nerve damage)
Slide 2 - Chemical and Mechanical pain after nerve injury
- Touch is vital
- Damage impulses
- Touch sensation
- Physiology and morphological lay
- Cell bodies
- Dorsal root
Slide 3 - TAFA4?
- Is protein
- Sensory neutrons
- Prevent pain after injury
- C-low threshold mechanoreceptors (C-LTMRs)
Slide 4 - TAFA4 Experiment
- In France studies were carried out on by Aziz Moqrich of Aix-Marseille-university.(Delfini et al.)
- TAFA4 could stop hypersensitivity
- Mice that doesn't contain TAFA4
- TAFA4 abolishing hypersensitivity
- (Delfini et al.)
Slide 5 - CLTMs?
- Are unmyelinated (Li 2011)
- Mammals's Hairy skin
- Transport of pleasant touch sensations
Slide 6 - Evidence
- Transducers of pleasant touch
- Painful touch after injury
- Qiufu Ma from Harvard Medical Science revealed that:
- Without presence of CLTMs
- Preventing their development
- Levels of hypersensitivity
Slide 7 - Who is Qiufu Ma?
- Research on two areas
- 1- understand genetic program
- > control specific sensory labelled
- 2- characterize neural circuits
- > Interaction distinct sensory labelled
Slide 8 - Qiufu Ma Popular Quote
- " We are interested in studying the neural
- Circuits involved with the
- Sense of pain, itch, touch
- And temperature" (Ma)
Slide 9 - Study conducted by Delfini et al. (2013)
- Study conducted by Delfini et al. (2013)
- Chemokine-like secreted protein TAFA4
- C-low-threshold (CLTMs)
- TAFA4 resist pain
- Glutamate from C-LTMRs
- Loss of glutamate
- Resistance to hypersensitivity
- Loss of C-LTMRs
- Removes the following:
- 1- Glutamate
- 2- TAFA4 protein
Slide 10 - Conclusion
- TAFA4 has claiming effect on hypersensitivity
- TAFA4 resist pain by the promotion of glutamate release in CLTMs.
- CLTMs and TAFA4 work together
- Lower hypersensitivity
- CLTMs release glutamate through TAFA4
- TAFA4 induces outward current in spinal cord neurons
- Inputs from CLTMs
- Excited spinal cord neurons
Slide 11 - References:
- 1- Coxworth, Ben. 2015. Web. 31 Mar. 2015.
- 2- Delfini MC, et al. 'TAFA4, A Chemokine-Like Protein, Modulates Injury-Induced Mechanical And Chemical Pain Hypersensitivity In Mice. - Pubmed - NCBI'. Ncbi.nlm.nih.gov. N.p., 2015. Web. 29 Mar. 2015.
- 3- Delfini, Marie-Claire et al. 'TAFA4, A Chemokine-Like Protein, Modulates Injury-Induced Mechanical And Chemical Pain Hypersensitivity In Mice'. Cell Reports 5.2 (2013): 378-388. Web. 27 Mar. 2015.
- 4- Gel-coated implants could reverse paralysis caused by nerve damage,. New Technology Could Facilitate The Healing Of Damage Nerves. 2015. Web. 16 Apr. 2015
- 5- Li, L. (2011). The functional organization of cutaneous low-threshold mechanosensory neurons. - PubMed - NCBI. [online] Ncbi.nlm.nih.gov. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22196735 [Accessed 31 Mar. 2015].
- 6- MedicineNet.com,. Multiple Sclerosis Pictures, Symptoms And Treatment. 2015. Web. 12 Apr. 2015.
- 7- Seal, R. (2009). Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. - PubMed - NCBI. [online] Ncbi.nlm.nih.gov. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19915548 [Accessed 31 Mar. 2015].
- 8- Solis, Michele. 'TAFA4 Protein Calms Painful Touch'. Pain Research Forum. N.p., 2015. Web. 30 Mar. 2015.
- 9- Woolf, Clifford J. 'Pain Hypersensitivity'. Wellcome.ac.uk. N.p., 2015. Web. 30 Mar. 2015.
Slide 12 - Name: Sandy Ieleshaa
- SID: 17521736
- Thank you