chloropromaznie presentaon mix
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Slide 1 - Chlorpromazine and haloperidol
- By Altaf Al Bahadli
Slide 2 - Schizophrenia
- Causes of schizophrenia
- Daniel’s story
- Chlorpromazine /haloperidol and what are they used for
- Proton channel
Slide 3 - Schizophrenia
- What is schizophrenia?
- Schizophrenia is mental illness
- Schizophrenia makes the person find it
- difficult to communicate with the society
- Schizophrenia occurs in about 1% of the total population
- Unknown cause
Slide 4 - Causes of schizophrenia
- Even though it remains unknown it can rely on some factors such as :
- Chemical process in the brain
- Abnormality of brain structure
Slide 5 - Daniel’s story
- Daniel’s story
- Daniel is 21 years old. Six months ago, he was doing well in college and holding down a part-time job in the stockroom of a local electronics store. But then he began to change, becoming increasingly paranoid and acting out in bizarre ways. First, he became convinced that his professors were “out to get him” since they didn’t appreciate his confusing, off-topic classroom rants. Then he told his roommate that the other students were “in on the conspiracy.” Soon after, he dropped out of school.
- From there, things just got worse. Daniel stopped bathing, shaving, and washing his clothes. At work, he became convinced that his boss was watching him through surveillance bugs planted in the store’s television sets. Then he started hearing voices telling him to find the bugs and deactivate them. Things came to a head when he acted on the voices, smashing several TVs and screaming that he wasn’t going to put up with the “illegal spying” any more. His frightened boss called the police, and Daniel was hospitalized(Mental Healthy, 2015)
Slide 6 - chlorpromazine
- Treatment of schizophrenia is chlorpromazine
- Works by dopamine receptor
- Dopamine is natural compound involved in transmitting messages between brain cells
- Increasing level of dopamine
- negative symptoms had been mainly because lack of dopamine
Slide 7 - Proton current
- bases which can increase the intracellular pH
- Chlorpromazine and haloperidol are strong blockers of dopamine receptor
- Voltage-gated proton channels
- NADPH oxidase transport electrons across the plasma membrane
- voltage dependence of proton channel is affected by PH
Slide 8 - Voltage gated proton program usually conveyed inside immune system such as microglia
- NADPH oxidase transfer electrons to the plasma membrane to decrease molecular oxygen
- Proton channels are suitable for chlorpromazine and haloperidol, which is considered for vital for keeping NADPH oxidase active.
Slide 9 - Effect of different concentration
- “ the effect of different concentrations of each antipsychotic on proton current inhibition are shown in this graph. The shown amplitude were measured while treating the cells for 30 min with each antipsychotic at the indicated concentration(shin and song,2014)
Slide 10 - Conclusion
- schizophrenia is one of the most dangerous disease among mental illness. It is one of the disease that researches did not find a particular cause and treatment.
- It is controlled by chlorpromazine and haloperidol
- Chlorpromazine and haloperidol, both typical antipsychotic drugs, potently inhibited the voltage-gated proton currents in BV2 microglial cells.
- As proton channel of voltage is affected by PH, then outward PH gradient of the plasma membrane decreases
- Chlorpromazine is more Potent inhibitor than haloperidol it works by suppressing dopamine receptor in the brain
- Chlorpromazine and haloperidol are weak bases that can increase the intracellular pH, whereby they reduce the proton gradient and affect channel gating.
- Dopamine works as a neurotransmitter in the brain which controls movement and Psychosis can be caused during metabolism problem .
Slide 11 - Thank
Slide 12 - Referencing/bibliography
- Cochrane.org,. 'Haloperidol Versus Chlorpromazine For Schizophrenia | Cochrane'. N.p., 2015. Web. 24 May 2015
- de Manzano, Ö., Cervenka, S., Karabanov, A., Farde, L. and Ullén, F. (2010). Thinking Outside a Less Intact Box: Thalamic Dopamine D2 Receptor Densities Are Negatively Related to Psychometric Creativity in Healthy Individuals. PLoS ONE, 5(5), p.e10670.
- Faculty.washington.edu, (2015). Neuroscience for Kids - Schizophrenia. [online] Available at: https://faculty.washington.edu/chudler/schiz.html [Accessed 12 May 2015].
- Google.com.au, (2015). mri of schizophrenic and not schizophrenic - Google Search. [online] Available at: https://www.google.com.au/search?q=mri+of+schizophrenic+and+not+schizophrenic&safe=active&biw=1366&bih=673&source=lnms&tbm=isch&sa=X&ei=DTlTVeKPF9Ok8AWM9YHICw&ved=0CAYQ_AUoAQ#imgrc=KqLSd5dXVcA7QM%253A%3BQgR_kt1QiW9oqM%3Bhttp%253A%252F%252Fwww.jamesdisabilitylaw.com%252Fimages%252FSchizophrenia_MRI_Scans.gif%3Bhttp%253A%252F%252Fwww.jamesdisabilitylaw.com%252Fschizophrenia.htm%3B570%3B376 [Accessed 14 May 2015
- Mental Healthy, (2015). Schizophrenia | Mental Healthy. [online] Available at: http://www.mentalhealthy.co.uk/other/schizophrenia [Accessed 12 May 2015]..
- Mental Health America,. 'Schizophrenia'. N.p., 2015. Web. 18 May 2015.
- Medscape.com,. 'Haloperidol Versus Chlorpromazine For Treatment Of Schizophrenia'. N.p., 2015. Web. 24 May 2015.
- . Shin, H. and Song, J. (2014). Antipsychotics, chlorpromazine and haloperidol inhibit voltage-gated proton currents in BV2 microglial cells. European Journal of Pharmacology, 738, pp.256-262.