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  1. Pain and plasticity of the central nervous system

    Slide 1 - Pain and plasticity of the central nervous system

    • Research based on the findings of “Functional Connections Formed by Saphenous Nerve Terminal Sprouts in the Dorsal Horn Following Neonatal Sciatic Nerve Section” by Peter Shortland and Maria Fitzgerald
    • Laura Certoma 17383921
  2. Findings in Functional connections…

    Slide 2 - Findings in Functional connections…

    • Terminal sprouts of saphenous nerve in dorsal horn made functional connections in damaged sciatic nerve terminals
    • These sprouts overcompensate by exciting more neurons and having a larger number of synapses than normal
    • (Shortland & Fitzgerald 1991)
  3. Sprouting

    Slide 3 - Sprouting

    • Used synonymously as ‘nerve regeneration’
    • “The regrowth and reconnection of viable and functional neural connections damaged by transection or other trauma”*
    • Growth of AXONS and projection of DENDRITES
    • *(Nerve regeneration 2002)
    • (St John 2014)
    • (Neural Engineering)
  4. Functional connections from peripheral damage

    Slide 4 - Functional connections from peripheral damage

    • Tissue damage increases synaptic function and is activity dependent
    • Neonatal spinal cord function differs to adult
    • Adult: inflammation enhances glycinergic inhibition
    • Neonate: damage may increase glutamatergic synapses in dorsal horn
    • (Baccei 2010)
  5. The pain matrix

    Slide 5 - The pain matrix

    • The conscious feeling and action of pain
    • Lateral areas of pain matrix locate and measure the intensity of pain
    • Medial areas code for the affect of pain and emotion associated with the pain
    • (Cortelli et al. 2013)
    • (Martin 2003)
  6. Conclusion

    Slide 6 - Conclusion

    • Initial report by Shortland & Fitzgerald shows that plasticity in spinal cord makes functional changes by nerve sprouting
    • This plasticity is induced by damage, resulting in pain
    • The pain matrix is a circuitry in the cortex that locates and manages pain sensation
  7. References

    Slide 7 - References

    • Baccei, ML 2010, 'Modulation of developing dorsal horn synapses by tissue injury', Ann N Y Acad Sci, vol. 1198, pp. 159-67.
    • Cortelli, P, Giannini, G, Favoni, V, Cevoli, S & Pierangeli, G 2013, 'Nociception and autonomic nervous system', Neurol Sci, vol. 34 Suppl 1, pp. S41-6.
    • Martin, J 2003, Neuroanatomy text and atlas, 3rd edn, McGraw Hill, New York.
    • Nerve regeneration 2002, McGraw-Hill, viewed 14th April 2015, <http://medical-dictionary.thefreedictionary.com/nerve+regeneration>.
    • Neural Engineering, viewed 14th April 2015, <http://orion.bme.columbia.edu/~kam/research/research.htm>.
    • Shortland, P & Fitzgerald, M 1991, 'Functional Connections Formed by Saphenous Nerve Terminal Sprouts in the Dorsal Horn Following Neonatal Sciatic Nerve Section', European Journal of Neuroscience, vol. 3, no. 5, pp. 383-96.
    • St John, J 2014, Trigeminal nerve cells of zebrafish in vivo, viewed 14th April 2015, <http://www.griffith.edu.au/science-aviation/eskitis-institute/staff/st-john-group/james-st-john>.
    • Suppa, A, Biasiotta, A, Belvisi, D, Marsili, L, La Cesa, S, Truini, A, Cruccu, G & Berardelli, A 2013, 'Heat-evoked experimental pain induces long-term potentiation-like plasticity in human primary motor cortex', Cereb Cortex, vol. 23, no. 8, pp. 1942-51.